Contests between these sides have been tough to call in recent years, with both teams proving capable of turning in match-winning displays. The results are split this season between the sides, although Tottenham's January victory was emphatic.
The FA Cup presents a final chance for both managers, who will be desperate to claim silverware this season. Tottenham have proven tried and tested goal-scorers in the cup, bagging at least two goals in 10 of their last 11 matches in the tournament.
Spurs will have to account for United stopper David de Gea, though, who has kept 21 clean sheets in all competitions so far this term, more than he has done in any other season.